Colorimetric Method for Instant Detection of Lysine and Arginine Using Novel Meldrum's Acid‐Furfural Conjugate

In the past few years Meldrum's acid furfural conjugate (MAFC) have been extensively explored as starting material for synthesis of photo switchable donor acceptor stenhouse adducts (DASA). Hereby, we interaction MAFC with various amino acids. To our surprise, nitrogen rich acids like lysine and arginine interact spontaneously to give colored adduct immediately, whereas other acids, including histidine, didn't show any coloration. Naked eye detection in benign solvent make this reagent an attractive new entry collection chemosensors colorimetric arginine. Intense coloration corresponds absorption at 514 nm under UV-Vis spectrometer. Lowest concentration 100 μm can be detected NMR titrations reveals that appearance color is due ring opening a leads formation conjugated triene species. Compared previously reported arginine, offers advantages simple synthesis, easy handling, high speed, low cost, good sensitivity/selectivity.